Relationship of dementia and visual hallucinations in tremor and non-tremor dominant Parkinson's disease
Identifieur interne : 001498 ( Main/Exploration ); précédent : 001497; suivant : 001499Relationship of dementia and visual hallucinations in tremor and non-tremor dominant Parkinson's disease
Auteurs : Abdul Qayyum Rana [Canada] ; Haris Munirvaid [Canada] ; Adnaan Edun [Canada] ; Okan D [Turquie] ; Mohammed A. Rana [Canada]Source :
- Journal of the neurological sciences [ 0022-510X ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objectives: Both visual hallucinations and cognitive dysfunction are experienced by a significant number of patients with Parkinson's disease. There were three main objectives of this study: (1) to determine if there is a difference in the prevalence of dementia in patients with tremor versus non-tremor dominant Parkinson's; (2) to determine if there is a difference of prevalence of visual hallucinations in patients with tremor and non-tremor dominant Parkinson's disease; and (3) to determine if there is a relationship between visual hallucinations and dementia in Parkinson's disease patients. Background: Dementia and visual hallucinations are common non-motor symptoms of Parkinson's disease that affect a significant number of patients. Previous research has shown that visual hallucinations may be predictive of future onset of dementia. We wanted to compare the prevalence of these non-motor symptoms in tremor vs. non-tremor dominant Parkinson's disease, although previous research has shown that dementia may be more common in the akinetic rigid variant of Parkinson's disease without tremor. Visual hallucinations have not yet been studied in this way. Methods: We performed a retrospective chart analysis on 314 patients with Parkinson's disease in this study. Patients meeting the inclusion criteria were stratified into several categories based on the presence or absence of tremor dominant PD, akinetic rigid dominant PD, dementia and visual hallucinations. Nonparametric tests were used for performing statistical analyses. The Chi Squared test was used for the analysis of categorical variables. Results: Patients without tremor had a higher prevalence of dementia (29%) than those with tremor (14%). There was no difference in visual hallucinations in tremor versus non-tremor patients, although there was a significant trend between tremor and visual hallucinations in female patients. A significant correlation was found between dementia and visual hallucinations in the sample, however further investigation showed this was largely associated with female Parkinson's disease patients.
Affiliations:
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Rana</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>York University Toronto</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>York University Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Tremor</term><term>Visual hallucination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence</term><term>Hallucination visuelle</term><term>Tremblement</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Both visual hallucinations and cognitive dysfunction are experienced by a significant number of patients with Parkinson's disease. There were three main objectives of this study: (1) to determine if there is a difference in the prevalence of dementia in patients with tremor versus non-tremor dominant Parkinson's; (2) to determine if there is a difference of prevalence of visual hallucinations in patients with tremor and non-tremor dominant Parkinson's disease; and (3) to determine if there is a relationship between visual hallucinations and dementia in Parkinson's disease patients. Background: Dementia and visual hallucinations are common non-motor symptoms of Parkinson's disease that affect a significant number of patients. Previous research has shown that visual hallucinations may be predictive of future onset of dementia. We wanted to compare the prevalence of these non-motor symptoms in tremor vs. non-tremor dominant Parkinson's disease, although previous research has shown that dementia may be more common in the akinetic rigid variant of Parkinson's disease without tremor. Visual hallucinations have not yet been studied in this way. Methods: We performed a retrospective chart analysis on 314 patients with Parkinson's disease in this study. Patients meeting the inclusion criteria were stratified into several categories based on the presence or absence of tremor dominant PD, akinetic rigid dominant PD, dementia and visual hallucinations. Nonparametric tests were used for performing statistical analyses. The Chi Squared test was used for the analysis of categorical variables. Results: Patients without tremor had a higher prevalence of dementia (29%) than those with tremor (14%). There was no difference in visual hallucinations in tremor versus non-tremor patients, although there was a significant trend between tremor and visual hallucinations in female patients. A significant correlation was found between dementia and visual hallucinations in the sample, however further investigation showed this was largely associated with female Parkinson's disease patients.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Turquie</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Qayyum Rana, Abdul" sort="Qayyum Rana, Abdul" uniqKey="Qayyum Rana A" first="Abdul" last="Qayyum Rana">Abdul Qayyum Rana</name></noRegion><name sortKey="Edun, Adnaan" sort="Edun, Adnaan" uniqKey="Edun A" first="Adnaan" last="Edun">Adnaan Edun</name><name sortKey="Munirvaid, Haris" sort="Munirvaid, Haris" uniqKey="Munirvaid H" first="Haris" last="Munirvaid">Haris Munirvaid</name><name sortKey="Rana, Mohammed A" sort="Rana, Mohammed A" uniqKey="Rana M" first="Mohammed A." last="Rana">Mohammed A. Rana</name></country><country name="Turquie"><noRegion><name sortKey="D, Okan" sort="D, Okan" uniqKey="D O" first="Okan" last="D">Okan D</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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